ChelationNation.info
  Each metal poisons differently
              ...Introducing Gadolinium

Gadolinium must be chelated before injection.  In the body, it then becomes un-glued...

      Up To Date Resources                       Real Science                     Bias Toward No One
  • 99% of Gadolinium exposures are via MRI injections. Workplace exposures and poisoning does occur.
  • Babies and infants are exposed to MRI gado.
  • Gadolinium injection can take many years to leave the body.
  • The top three most popular Gadolinium injection products are also the most unstable and poisonous of the 7 total on the market.
  • Gadolinium symptoms can appear 6+ months after injection, so tracing the problem is very difficult.
  • Patients with kidney disease will have immediate poisoning, while patients with perfect kidneys will get chronic (undiagnosed) poisoning from Gadolinium.
  • The MRI you just had to investigate your symptoms, itself, may be actually promoting or even CAUSING the worsening of your disease.
Aluminum
Arsenic
Cadmium
Gadolinium
Lead
Mercury
Nickle
Gadolinium was first smelted and "discovered" in the year 1880.  Gadolinium was first used in industry in the 1980's.  Gadolinium was first used in medicine in the year 1988.  Gadolinium has been known to be a potent medical poison since the year 1997.    Anti-gadolinium lawsuits first began in the year 2008.  Today, Gadolinium is given to tens on millions of patients each year in the US alone.  Gadolinium now has expanded FDA black box warnings as of 2010.
Some Examples of Peer Reviewed Research
*files are grouped by year, but not by publishing date


2011
Recent hot topics in contrast media
http://www.springerlink.com/content/qv4r61613t10n22x/fulltext.pdf


2011     
Toxic effects of mercury, lead and gadolinium on vascular reactivity
http://www.scielo.br/pdf/bjmbr/v44n9/1088.pdf

2010      
Gadolinium-based Magnetic Resonance Contrast Agents and Nephrogenic Systemic Fibrosis
http://www.touchnephrology.com/articles/gadolinium-based-magnetic-resonance-contrast-agents-and-nephrogenic-systemic-fibrosis?page=0,4

2010     
Nephrogenic systemic fibrosis presenting as myopathy: A case report with histopathologic correlation
http://www.nmd-journal.com/article/S0960-8966(10)00166-5/abstract

2010
Novel Sorbents for Removal of Gadolinium-Based Contrast Agents in Sorbent Dialysis and Hemoperfusion: Preventive
Approaches to Nephrogenic Systemic Fibrosis (NSF)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862574/pdf/nihms118116.pdf

2010
The Biodistribution of [153Gd]Gd-Labeled Magnetic Resonance Contrast Agents in a Transgenic Mouse Model of Renal Failure Differs Greatly from Control Mice
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180881/?tool=pubmed

2010
Impaired mitochondrial function and oxidative stress in rat cortical neurons: implications for gadolinium-induced neurotoxicity.
http://www.ncbi.nlm.nih.gov/pubmed/20398695

2009
Gadolinium Containing Containing Contrast Agent Promotes Multiple Myeloma Cell Growth: Implication for Clinical Use of MRI in Myeloma 
http://myeloma.org/pdfs/ASH2009_Fulciniti_1809.pdf

2010
Zinc Transmetallation and Gadolinium Retention after MR Imaging: Case Report
http://radiology.rsna.org/content/257/3/670.full

2009
http://radiology.rsna.org/content/253/2/390.full.pdf

2009
Persistence of Gadolinium Contrast Enhancement in CSF: A Possible Harbinger of Gadolinium Neurotoxicity?
http://www.ajnr.org/content/30/1/e1.full.pdf

2009
Long-term retention of gadolinium in the skin of rodents following the administration of gadolinium-based contrast agents
http://www.springerlink.com/content/30g331p7p8438w21/fulltext.pdf

2009
Gadolinium-Based Contrast Agents & Nephrogenic Systemic Fibrosis:  FDA Briefing Document
http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/DrugSafetyandRiskManagementAdvisoryCommittee/UCM190850.pdf

2008
Possibly enhanced Gd excretion in dialysate, but no major clinical benefit of 3–5 months of treatment with sodium thiosulfate in late stages of nephrogenic systemic fibrosis
http://ndt.oxfordjournals.org/content/23/10/3280.long

2008
Nephrogenic Systemic Fibrosis with Multiple Calcification and Osseous Metaplasia
http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-0518&html=1

2007
Case-control study of gadodiamide-related nephrogenic systemic fibrosis
http://ndt.oxfordjournals.org/content/22/11/3174.full.pdf+html

2007
http://www.diagnosticimaging.com/conference-reports/ismrm2007/article/113619/1184977

2007
Dermal inorganic gadolinium concentrations: evidence for in vivo transmetallation and long-term persistence in nephrogenic systemic fibrosis.
http://www.ncbi.nlm.nih.gov/pubmed/18067485

2007
Nephrogenic Fibrosing Dermopathy Associated with Exposure to Gadolinium-Containing Contrast Agents --- St. Louis, Missouri, 2002--2006
http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5607a1.htm

2007
New Insights into Nephrogenic Systemic Fibrosis, Sundararaman Swaminathan and Sudhir V. Shah
http://jasn.asnjournals.org/content/18/10/2636.full

2007
Nephrogenic Systemic Fibrosis: A Mysterious Disease in Patients with Renal Failure—Role of Gadolinium-Based
Contrast Media in Causation and the Beneficial Effect of Intravenous Sodium Thiosulfate
http://cjasn.asnjournals.org/content/2/2/258.full.pdf

2007
Nephrogenic Systemic Fibrosis Mimicking Inflammatory Breast Carcinoma
http://www.archivesofpathology.org/doi/pdf/10.1043%2F1543-2165(2007)131%5B145%3ANSFMIB%5D2.0.CO%3B2

2007
What nephrologists need to know about gadolinium
http://www.nature.com/nrneph/journal/v3/n12/full/ncpneph0660.html

2006
Methods of diagnosing and alleviating gadolinium toxicity        Patent Application
http://www.freshpatents.com/Methods-of-diagnosing-and-alleviating-gadolinium-toxicity-dt20080612ptan20080138440.php

2003
Pseudohypocalcemia with MR Imaging Contrast Agents: A Cautionary Tale
http://radiology.rsna.org/content/227/3/627.full

2002
Are Gadolinium-based Contrast Media Really Safer than Iodinated Media for Digital Subtraction Angiography in Patients with Azotemia?
http://radiology.rsna.org/content/223/2/311.full#sec-4

1995
Neurotoxic Effects of Gadopentetate Dimeglumine: Behavioral Disturbance and Morphology after Intracerebroventricular
Injection in Rats
http://www.ajnr.org/content/17/2/365.full.pdf


1965
SOFT-TISSUE CALCIFICATION INDUCED BY RARE EARTH METALS AND ITS PREVENTION BY SODIUM PYROPHOSPHATE
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1510795/pdf/bripharmchem00023-0007.pdf






"TRANSMETALLATION" is a big word that means "swapping one metal out for another."
Gadolinium can only be "safely" injected into a body if it is "caged/bound/chelated" inside a safe molecule.  Inside the cage it can still be magnetic (useful for magnetic resonance imaging-MRI), and yet it is not allowed out of the cage to "react" with the proteins etc of the body, as it is poisonous.  HOWEVER, other heavy metals in a body also want to get inside the cage, and are known to UNLOCK the cage, jump into the cage and kick the gadolinium out.  For example, Zinc denture cream is known to release Gadolinium from it's cage.  Mercury, Lead and others may do something similar.  This unleashed Gadolinium creates chronic disease states.

"EXTRAVASATION" is a big word that means the needle missed (or poked through) the vein and what was supposed to go into your bloodstream got left behind in a muscle or nearby tissue where it takes much longer to get removed from the body as has longer to react with other things.  Gadolinium has more time to "unzip" from it's binder and be left behind, in your body, instead of exiting through your kidneys as it is "supposed to".

Some symptoms associated with toxic levels of Gadolinium

Skin changes akin to fibrosis of the skin and muscles, especially on limbs, eye changes, optic floaters, large lumps on limbs near joints.

Tips on testing for Gadolinium in the body
Urine challenge with IV EDTA or biopsy or suspicious tissue are the only ways to reliably find gadolinium. Mayo clinic does blood serum testing for it.

Tips on Chelation of Gadolinium from the body
EDTA iv's in a body with with lots of silver fillings in your mouth may cause mobilization of mercury, so it is necessary to read up on that if you have them.  I.V. EDTA is known to chelate Gadolinium, while oral EDTA does not.  Suppository EDTA should work, but  we don't know how much. DMSA does not remove gadolinium. Experimentation with the use of DTPA is needed.   Chelation of Gadolinium is fairly new in online patient experience, circa roughly 2009.